In adults (aged 18 and over), Benepali can be used for: moderate or severe rheumatoid arthritis; psoriatic arthritis; Tell your doctor immediately, or go to the casualty department at your nearest hospital. Good luck. In a double-blind, placebo-controlled, randomised clinical study in adult patients with psoriatic arthritis, 184 patients also received a multivalent pneumococcal polysaccharide vaccine at week 4. Changes since initial authorisation of medicine, Initial marketing-authorisation documents, Committee for Medicinal Products for Human Use, Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 16-19 November 2015, Send a question to the European Medicines Agency, International non-proprietary name (INN) or common name, Anatomical therapeutic chemical (ATC) code, Date of issue of marketing authorisation valid throughout the European Union. If re-treatment with Benepali is indicated, the above guidance on treatment duration should be followed. Anyone on Benepali had root canal treatment. In another active-controlled, double-blind, randomised study, clinical efficacy, safety, and radiographic progression in RA patients treated with etanercept alone (25 mg twice weekly), methotrexate alone (7.5 to 20 mg weekly, median dose 20 mg), and the combination of etanercept and methotrexate initiated concurrently were compared in 682 adult patients with active rheumatoid arthritis of 6 months to 20 years duration (median 5 years) who had a less than satisfactory response to at least 1 disease-modifying antirheumatic drug (DMARD) other than methotrexate. Benepali, alone or in combination with methotrexate, has been shown to reduce the rate of progression of joint damage as measured by X-ray and to improve physical function. bitBut I still have RA. European Medicines AgencyDomenico Scarlattilaan61083 HS AmsterdamThe Netherlands. There have been reports of hypoglycaemia following initiation of etanercept in patients receiving medicinal products for diabetes, necessitating a reduction in anti-diabetic medicinal products in some of these patients. gilbert lani kauhi net worth; porto's parisian cake calories Only take the pens you'll need for your stay. Treatment of polyarthritis (rheumatoid factor positive or negative) and extended oligoarthritis in children and adolescents from the age of 2 years who have had an inadequate response to, or who have proved intolerant of, methotrexate. The use of etanercept in combination with other systemic therapies or phototherapy for the treatment of psoriasis has not been studied. With a quick, dart-like motion, insert the needle fully into the skin. Differences from adults and other special considerations are discussed in the following paragraphs. Chickenpox: Tell your doctor if you or the child are exposed to chickenpox when using Benepali. Patients developing a serious infection should stop Benepali treatment. Benepali is used either in combination with methotrexate (a medicine that acts on the immune system) in adults with moderate or severe disease who have not responded adequately to other treatments, or on its own if methotrexate is not suitable for the patient. Original PDF (ema.europa.eu), 1. Preclinical data about peri- and postnatal toxicity of etanercept and of effects of etanercept on fertility and general reproductive performance are not available. After discontinuation of etanercept, symptoms of arthritis generally returned within a month. At week 104, the mean change from baseline in the SPARCC score measured on MRI for all etanercept-treated subjects was 4.64 for the SIJ (n=153) and 1.40 the spine (n=154). Mean duration was approximately 3 to 5 days. Serious and fatal infections have been reported during use of etanercept; reported pathogens include bacteria, mycobacteria (including tuberculosis), viruses and fungi. The efficacy of etanercept was compared to methotrexate in a randomised, active-controlled study with blinded radiographic evaluations as a primary endpoint in 632 adult patients with active rheumatoid arthritis (< 3 years duration) who had never received treatment with methotrexate. In plaque psoriasis, infiltration by inflammatory cells, including T-cells, leads to increased TNF levels in psoriatic lesions compared with levels in uninvolved skin. These measures will help protect the environment. This protein is found at high levels in patients with the diseases that Benepali is used to treat. Several adverse events were reported more commonly in 69 juvenile idiopathic arthritis patients receiving 3 months of etanercept compared to the 349 adult rheumatoid arthritis patients. The known side effects of Benepali include the following in groups of decreasing frequency: Infections (including colds, sinusitis, bronchitis, urinary tract infections and skin infections); injection site reactions (including bleeding, bruising, redness, itching, pain, and swelling) (these do not occur as often after the first month of treatment; some patients have developed a reaction at an injection site that was recently used); and headache. In the controlled clinical trials that allowed concomitant treatment with etanercept and methotrexate, the frequency (incidence proportion) of interstitial lung disease was 0.47% (frequency uncommon). Developmental toxicity studies performed in rats and rabbits have revealed no evidence of harm to the foetus or neonatal rat due to etanercept. In placebo-controlled trials, no increase in the incidence of serious infections (fatal, life-threatening, or requiring hospitalisation or intravenous antibiotics) was observed. Radiographic changes were assessed in the psoriatic arthritis study. A total of 2 malignancies were reported in clinical studies of approximately 2 years duration involving 240 etanercept-treated psoriatic arthritis patients. It is very important that you tell your doctor if you or the child have ever had tuberculosis, or have been in close contact with someone who has had tuberculosis. The educational materials also include a reminder that Benepali is not for use in children and adolescents who weigh less than 62.5 kg. Benepali 50 mg solution for injection in pre-filled syringe. However iv to have 2 extractions of root left on my upper gum (dreading) & 3 fillings all done on the same day as I opted to be knocked out as the over whelming thought on its own was enough to put me into a state of panic my daughter will take me off course & collect me I AM HOWEVER REAL SCARED OF THE HEALING TIME DUE TO MY SALVISALIZINE & BENEPALI I DONT KNOW WEATHER I SHOULD JUST STOP THEM FOR NOW MY APPOINTMENT IS THE 5th JUNE ANY ADVICE GUYS (except call your Rheumatolgy Clinic) as I can never get hold of anyone at the present time. Rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis including ankylosing spondylitis The usual dose is 25mg given twice a week or 50mg once a week as an injection under the skin. If an alternate dose is required, other etanercept products offering such an option should be used. Patients weighing 62.5 kg or more, may be dosed using a fixed-dose pre-filled syringe or pre-filled pen. The impact of advanced age was studied in the population pharmacokinetic analysis of etanercept serum concentrations. These mean concentrations in patients with paediatric plaque psoriasis were similar to the concentrations observed in patients with juvenile idiopathic arthritis (treated with 0.4 mg/kg etanercept twice weekly, up to maximum dose of 50 mg per week). There have been reports of inflammatory bowel disease and uveitis in JIA patients being treated with etanercept from post-marketing sources, including a very small number of cases indicating a positive rechallenge. Hi HevJ, I would have the dental treatment and then just see how you feel after that theres only you knows your body and how your feeling the only thing i can add is the fact that the benapali works similar to MTX and can take up to 12 weeks to start working so time for your teeth to heal in the meantime, Good luck Reply (0) Report A total of 401 patients were enrolled, from which 203 were treated with etanercept. The Benepali pre-filled syringe is for a subcutaneous injection. Adult patients had serum samples tested for autoantibodies at multiple timepoints. There is an increased background risk for lymphoma and leukaemia in rheumatoid arthritis patients with long-standing, highly active, inflammatory disease, which complicates risk estimation. In addition, one study found more birth defects when the mother had received etanercept in pregnancy, compared with mothers who had not received etanercept or other similar medicines (TNF-antagonists), but there was no particular kind of birth defect reported. a Patients who did not complete 12 months in the study were considered to be non-responders. Hi looking for some info on Benepali & dental treatment I was on biological meds before & was informed the unyielding time scale to stop meds before dental treatment was 3 weeks but I'm unsure of the time scale prior to dental procedures on Benepali I also take salphasalizine with the biological meds. Rare (may affect up to 1in 1,000people), Serious allergic reactions (including severe localised swelling of the skin and wheezing); lymphoma (a type of blood cancer); leukaemia (cancer affecting the blood and bone marrow); melanoma (a type of skin cancer); combined low platelet, red, and white blood cell count; nervous system disorders (with severe muscle weakness and signs and symptoms similar to those of multiple sclerosis or inflammation of the nerves of the eyes or spinal cord); tuberculosis; new onset congestive heart failure; seizures; lupus or lupus-like syndrome. IT SHOULD BE INJECTED INTO THE THIGH, ABDOMEN, OR BACK OF THE UPPER ARM. Methotrexate needs to be stopped while taking antibiotics & until incisions are healed. Benepali treatment should be initiated and supervised by specialist physicians experienced in the diagnosis and treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, plaque psoriasis or paediatric plaque psoriasis. Your doctor will help you to decide whether the benefits of treatment outweigh the potential risk to your baby. Case series of 138 patients with RA, SpA or PsA treated with at least one dose of Benepali (n = 79) or Enbrel (n = 59). I think this with the meds surprised me Hi HevJ, I would have the dental treatment and then just see how you feel after that theres only you knows your body and how your feeling the only thing i can add is the fact that the benapali works similar to MTX and can take up to 12 weeks to start working so time for your teeth to heal in the meantime. There is generally no applicable use of etanercept in children aged below 2 years in the indication juvenile idiopathic arthritis. In an analysis in which all patients who dropped out of the study for any reason were considered to have progressed, the percentage of patients without progression (TSS change 0.5) at 12 months was higher in the etanercept group compared with the placebo group (73% vs. 47%, respectively, p 0.001). In study 1, the etanercept-treated group had a significantly higher proportion of patients with a PASI 75 response at week 12 (30%) compared to the placebo-treated group (2%) (p < 0.0001). If you do not remember until the day that the next injection is due, do not take a double dose (two doses on the same day) to make up for a forgottendose. Has anyone carried on taking Benepali while having root treatment?? Although there is elimination of radioactivity in urine after administration of radiolabelled etanercept to patients and volunteers, increased etanercept concentrations were not observed in patients with acute renal failure. Serious allergic reactions are rare. It is not intended to provide practical advice on how to use Benepali. In this study, most psoriatic arthritis patients receiving etanercept were able to mount effective B-cell immune response to pneumococcal polysaccharide vaccine, but titres in aggregate were moderately lower, and few patients had two-fold rises in titres compared to patients not receiving etanercept. Treatment should be discontinued in patients who show no response after 12 weeks. For more information, see the package leaflet. Two juvenile idiopathic arthritis patients developed varicella infection and signs and symptoms of aseptic meningitis, which resolved without sequelae. Hi looking for some info on Benepali & dental treatment I was on biological meds before & was informed the unyielding time scale to stop meds before dental treatment was 3 weeks but Im unsure of the time scale prior to dental procedures on Benepali I also take salphasalizine with the biological meds. Dimeric soluble receptors, such as etanercept, possess a higher affinity for TNF than monomeric receptors and are considerably more potent competitive inhibitors of TNF binding to its cellular receptors. Other etanercept products with appropriate dosage forms for children are available. Like all medicines, this medicine can cause side effects, although not everybody getsthem. Benepali treatment should be started and supervised by a specialist doctor who has experience in the diagnosis and treatment of the diseases that Benepali is used to treat. Hope this is of some help, would advise you check with your rheumatology team as this advise was a few years ago. Keep the pre-filled syringes or pens in the outer carton in order to protect from light. Benepali treatment should be initiated and supervised by specialist physicians experienced in the diagnosis and treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, plaque psoriasis or paediatric plaque psoriasis. quetzalcoatl offerings. The other ingredients are sucrose, sodium chloride, sodium dihydrogen phosphate monohydrate, disodium hydrogen phosphate heptahydrate, and water for injections (see section 2 Benepali contains sodium). In general, the adverse events in paediatric patients with juvenile idiopathic arthritis were similar in frequency and type to those seen in adult patients. However, any of the above symptoms may indicate an allergic reaction to Benepali, so you should seek immediate medical attention. Please tell your doctor if you or the child in your care have a history of alcoholabuse. However, limited safety data from a patient registry suggest that the safety profile in children from 2 to 3 years of age is similar to that seen in adults and children aged 4 years and older, when dosed every week with 0.8 mg/kg subcutaneously. Do not twist or bend the needle cover while removing it, as this may damage the needle. Swelling of the face, throat, hands, or feet, Feeling nervous or anxious, throbbing sensations, sudden reddening of the skin and/or a warm feeling, Severe rash, itching, or hives (elevated patches of red or pale skin that oftenitch), Signs of serious infections (including pneumonia, deep skin infections, joint infectionsand. root canal or extractions you have to stop your anti tnf. Congestive heart failure: Tell your doctor if you or the child have a history of congestive heart failure, because Benepali needs to be used with caution under these circumstances. The safety and efficacy profiles of the two etanercept treatment regimens were comparable at week 8 in their effect on signs and symptoms of RA; data at week 16 did not show comparability (non-inferiority) between the two regimens. The needle cover should not be removed while allowing the pre-filled syringe to reach room temperature. Live vaccines should not be given concurrently with Benepali. email etc . For centrally authorised veterinary medicines authorised or updated from February 2022, see theVeterinary Medicines Information website. Quality of life in psoriatic arthritis patients was assessed at every timepoint using the disability index of the HAQ. I contacted my rheumatology helpline for advise. Some patients receiving Benepali have developed skin cancers. If you are concerned with the appearance of the solution, then contact your pharmacist for assistance. Compared to placebo, treatment with etanercept resulted in statistically significant improvement in the ASAS 40, ASAS 20 and ASAS 5/6. Treatment with Benepali should continue until remission is achieved, for up to 24 weeks. Injection site reactions usually occurred in the first month. Each pre-filled pen contains 50 mg of etanercept. Please do not include any personal data, such as your name or contact details. In the postmarketing setting, cases of leukaemia have been reported in patients treated with TNF-antagonists. Physicians should exercise caution when considering the use of Benepali in patients with a history of recurring or chronic infections or with underlying conditions that may predispose patients to infections, such as advanced or poorly controlled diabetes. These are not usually serious and include throat . There have been postmarketing reports of interstitial lung disease (including pneumonitis and pulmonary fibrosis), some of which had fatal outcomes. In the double-blind and open-label psoriatic arthritis trials, 1 patient reported a serious infection (pneumonia). Whether used alone or in combination with methotrexate, Benepali can slow down the damage to your joints caused by the rheumatoid arthritis and improve your ability to do normal daily activities. There have been rare reports of CNS demyelinating disorders in patients treated with etanercept. Wegenersgranulomatosis: Benepali is not recommended for the treatment of Wegenersgranulomatosis, a rare inflammatory disease. Etanercept 25 mg was significantly superior to methotrexate for erosion scores at both 12 and 24 months. Compared to placebo, patients with rheumatic diseases treated with etanercept had a significantly higher incidence of injection site reactions (36% vs. 9%). FUJIFILM Diosynth Biotechnologies Denmark ApS. In clinical studies conducted for more than 2 years with 351 ankylosing spondylitis patients, 6 malignancies were reported in etanercept-treated patients. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. Treatment with etanercept 25 mg resulted in substantial improvement at 12 months, with about 44% of patients achieving a normal HAQ score (less than 0.5). Feeling full after eating a small amount , then indigestion.Hair Loss. If you type it in you may find a post or two there. Some of these patients have been under 50 years of age. Some vaccines, such as oral polio vaccine, should not be given while using Benepali. Combining the results of controlled clinical trials, more cases of NMSC were observed in patients receiving etanercept compared with control patients, particularly in patients with psoriasis. Enbrel (etanercept) is a prescription medication used to treat five chronic diseases including moderate to severe rheumatoid arthritis (RA), psoriatic arthritis (PsA), moderate to severe plaque psoriasis (PsO), ankylosing spondylitis (AS), and moderate to severe polyarticular juvenile idiopathic arthritis (JIA). Etanercept did not elicit dose-limiting or target organ toxicity in cynomolgus monkeys following twice weekly subcutaneous administration for 4 or 26 consecutive weeks at a dose (15 mg/kg) that resulted in AUC-based serum drug concentrations that were over 27-fold higher than that obtained in humans at the recommended dose of 25 mg. Radiographic progression: Comparison of etanercept vs. methotrexate vs. etanercept in combination with methotrexate in patients with RA of 6 months to 20 years duration (12 month results). Psoriatic arthritis in patients from the age of 12years and weighing 62.5kg ormore. TNF and lymphotoxin exist predominantly as homotrimers, with their biological activity dependent on cross-linking of cell surface TNFRs. Tell your doctor or pharmacist if you or the child are taking, have recently taken or might take any other medicines (including sulfasalazine). The observed rates and incidences in these clinical trials were similar to those expected for the population studied. Serious infections, sepsis, tuberculosis, and opportunistic infections, including invasive fungal infections, listeriosis and legionellosis, have been reported with the use of etanercept. Etanercept contains 934 amino acids and has an apparent molecular weight of approximately 150 kilodaltons. After 12 weeks of treatment, patients in the placebo group began treatment with blinded etanercept (25 mg twice a week); patients in the active treatment groups continued to week 24 on the dose to which they were originally randomised. A study was carried out to show that Benepali produces similar levels of the active substance in the body to Enbrel. Although no clinical trials have been performed evaluating etanercept therapy in patients with multiple sclerosis, clinical trials of other TNF antagonists in patients with multiple sclerosis have shown increases in disease activity. Posology and administration are the same as for adults 18-64 years of age. Significant advantages for etanercept in combination with methotrexate compared with etanercept monotherapy and methotrexate monotherapy were also observed after 24 months. abuse. If I am honest I was really taken aback by the nurse of Wednesday. It should be injected into the thigh, abdomen, or back of the upper arm (see image on theleft). Very common (may affect more than 1in 10people), Very rare (may affect up to 1in 10,000people), Not known (frequency cannot be estimated from availabledata). Malignancies, some fatal, have been reported among children, adolescents and young adults (up to 22 years of age) treated with TNF-antagonists (initiation of therapy 18 years of age), including etanercept, in the postmarketing setting. Benepali 50 mg solution for injection in pre-filled pen. This medicinal product contains less than 1mmol sodium (23mg) per 25mg, that is to say essentially sodium-free. For more information, see Biosimilar medicines. blood infection), such as high fever that may be accompanied by cough, shortness of breath, chills, weakness, or a hot, red, tender, sore area on the skin or joints; These are rare or uncommon side effects, but are serious conditions (some of which may rarely be fatal). Paediatric patients who require a dose other than a full 25 mg or 50 mg should not receive Benepali. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. No formal clinical trials have been conducted in children aged 2 to 3 years. Women of childbearing potential should be advised to use appropriate contraception to avoid becoming pregnant during Benepali therapy and for three weeks after discontinuation of therapy. Treatment of active and progressive psoriatic arthritis in adults when the response to previous disease-modifying antirheumatic drug therapy has been inadequate. medication to have dental work that involves Blood?..A good friend of mine is on MTX and Hi looking for some info on Benepali & dental treatment I was on biological meds before & was teeth sensitivity. These patients should be monitored for signs and symptoms of active HBV infection throughout therapy and for several weeks following termination of therapy. Patients weighing less than 62.5 kg should be accurately dosed on a mg/kg basis using the powder and solvent for solution for injection presentations or powder for solution for injection presentations (see below for dosing for specific indications). Administration of Benepali should be discontinued if a patient develops a serious infection. Some people may have reactions at the spot of the injection, such as redness, swelling or pain. In controlled clinical trials of etanercept across all indications, the frequency (incidence proportion) of interstitial lung disease in patients receiving etanercept without concomitant methotrexate was 0.06% (frequency rare). Attention! Etanercept may also modulate biologic responses controlled by additional downstream molecules (e.g., cytokines, adhesion molecules, or proteinases) that are induced or regulated by TNF. See Choose an injection site for guidance with choosing an injectionsite. Doses of 10 mg or 25 mg etanercept were administered subcutaneously (SC) twice a week for up to 24 months. Allergic reactions have included angioedema and urticaria; serious reactions have occurred. Good luck with the dentist hope it all goes ok, Hi,I also was due to start benepali,but due to root canal X 2 couldn't start,then following untold infections still haven't! The efficacy of etanercept versus other systemic therapies in patients with moderate to severe psoriasis (responsive to other systemic therapies) has not been evaluated in studies directly comparing etanercept with other systemic therapies. What you need to know before you use Benepali, 6. Simulation of dosing suggests that while older children (10-17 years of age) will have serum levels close to those seen in adults, younger children will have appreciably lower levels. Children and adults taking Benepali may have an increased risk of developing lymphoma or another cancer. I've had root canal treatment, I was told not to take it the week before and the week after having the work done and only start taking it again if everything is okay. The percentage of patients who developed new positive anti-double-stranded DNA antibodies was also higher by radioimmunoassay (15% of patients treated with etanercept compared to 4% of placebo-treated patients) and by Crithidia luciliae assay (3% of patients treated with etanercept compared to none of placebo-treated patients). To view profiles and participate in discussions please. In lactating rats following subcutaneous administration, etanercept was excreted in the milk and detected in the serum of pups. Talk to your doctor before taking Benepali. Allergic reactions; fever; rash; itching; antibodies directed against normal tissue (autoantibody formation). Today I have started on Benepali. Methotrexate doses were escalated from 7.5 mg/week to a maximum of 20 mg/week over the first 8 weeks of the trial and continued for up to 24 months. Periodic skin examination is recommended for all patients, particularly those with risk factors for skin cancer. Ive been on methotrexate for 5 years and can remember feeling overwhelmed at the beginning- over the years it became part n parcel of life! However, it cannot be excluded that the combination of etanercept with methotrexate could be associated with an increase in the rate of infections. Etanercept has been shown to improve physical function in patients with psoriatic arthritis, and to reduce the rate of progression of peripheral joint damage as measured by X-ray in patients with polyarticular symmetrical subtypes of the disease. At week 12, there was a statistically significant improvement in the SPARCC (Spondyloarthritis Research Consortium of Canada) score for the sacroiliac joint (SIJ) as measured by MRI for patients receiving etanercept. It is used for the treatment of the following diseases: Benepali contains the active substance etanercept and is a biosimilar medicine. Do not use the pre-filled syringe if it has been dropped onto a hard surface. Mean serum concentration profiles at steady state in treated RA patients were Cmax of 2.4 mg/l vs. 2.6 mg/l, Cmin of 1.2 mg/l vs. 1.4 mg/l, and partial AUC of 297 mg hr/l vs. 316 mg hr/l for 50 mg etanercept once weekly (n = 21) vs. 25 mg etanercept twice weekly (n = 16), respectively. The osmolality of the solution is 325 35 mOsm/kg. There is no apparent pharmacokinetic difference between males and females. One hundred and twenty-nine (129) new malignancies of various types were observed in 4,114 rheumatoid arthritis patients treated in clinical trials with etanercept for up to approximately 6 years, including 231 patients treated with etanercept in combination with methotrexate in the 2-year active-controlled study. lol, I had a tooth out on Wednesday my benepali had been due Sunday but I didn't take it till Thursday no real bleeding and socket is healing fine. Malignancies and lymphoproliferative disorders, Solid and haematopoietic malignancies (excluding skin cancers). Etanercept has not been studied in children aged less than 2 years. One hundred and twelve (112) patients were randomised to receive a dose of 25 mg of etanercept (n = 57) or placebo (n = 55) twice a week for 24 weeks. Radiographs of hands and wrists were obtained at baseline and months 6, 12, and 24. Appropriate screening tests, i.e., tuberculin skin test and chest X-ray, should be performed in all patients (local recommendations may apply). Continuous therapy beyond 24 weeks may be appropriate for some adult patients. Hi Guys wee update on my dental treatment firstly can I just say I went to my last appointment on my own (massive achievement) I wont say I wasnt scared I was petrified but felt the need to do this & did. Responses of patients with psoriatic arthritis in a placebo-controlled trial. Compared to placebo, treatment with etanercept resulted in significant improvements in the ASAS 20, ASAS 50 and ASAS 70 as early as 2 weeks after the initiation of therapy. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. Serious infections affect fewer than 1 in 100 patients treated with etanercept. The disability index score was significantly improved at all timepoints in psoriatic arthritis patients treated with etanercept, relative to placebo (p < 0.001). Never recap the needle. The primary measure of efficacy (ASAS 40) was a 40% improvement in at least three of the four ASAS domains and absence of deterioration in the remaining domain.
Can You Cash A Butterball Check At The Bank, Slake Durability Test Lab Report, Chancie Adams Obituary, United Airlines Flight Attendant Interview Process 2022, Articles B
Can You Cash A Butterball Check At The Bank, Slake Durability Test Lab Report, Chancie Adams Obituary, United Airlines Flight Attendant Interview Process 2022, Articles B